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Currently approved and commonly used GLP-1R agonists include exenatide (the synthetic form of Ex-4, a naturally occurring GLP-1R agonist), lixisenatide, dulaglutide liraglutide and semaglutide ( Figure 2 ) ( Figure 2 Exenatide, a peptide of 39 amino acids, has a much slower metabolism than endogenous GLP-1 (half-life of 3-4 h) (119, 120)

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Licensed health-care professionals are far more likely to prescribe responsibly, as both their reputation and medical license depend on patient safety. Dr